Changes in the 3D corneal structure and morphogeometric properties in keratoconus after corneal collagen crosslinking
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AuthorAlifa Pintado, Ramón; Piñero Llorens, David Pablo; Velázquez Blázquez, José Sebastián; Alió del Barrio, Jorge Luis; Cavas Martínez, Francisco; [et al.]
Knowledge AreaExpresión Gráfica en Ingeniería
SponsorsThis publication forms part of the Network for Cooperative Research in Health “OFTARED” – reference: RD16/0008/0012. We were funded by the Instituto de Salud Carlos III and co-funded by the European Regional Development Fund (ERDF), “A way to make Europe”. The author David P. Piñero has been supported by the Ministry of Economy, Industry and Competitiveness of Spain as part of program Ramón y Cajal, RYC-2016-20471.
Bibliographic CitationAlifa R, Piñero D, Velázquez J, Alió del Barrio JL, Cavas F, Alió JL. Changes in the 3D Corneal Structure and Morphogeometric Properties in Keratoconus after Corneal Collagen Crosslinking. Diagnostics. 2020; 10(6):397. doi:10.3390/diagnostics10060397
Keratoconus is an ectatic disorder that is presently considered one of the most prevalent reasons for keratoplasty. Corneal collagen crosslinking (CXL) is the only proven treatment option available that is capable of halting the progression of the disease by stabilizing the cone in 90% of cases, and by also reducing refractive error and maximal keratometry. This study assesses, by means of a 3D morphogeometric analysis procedure developed by our research team, the corneal structure changes that occur immediately after CXL treatment and during a 6 month follow-up period. A total of 19 eyes from 19 patients diagnosed with keratoconus who underwent CXL were included, and several variables derived from the morphogeometric analysis were calculated and evaluated for the pre-operative, 3 month postoperative, and 6 month postoperative states. Significant reductions were detected in central corneal thickness and corneal spherical-like root mean square (RMS) 3 months after surgery, with non-sign ...
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