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dc.contributor.authorAlifa Pintado, Ramón 
dc.contributor.authorPiñero Llorens, David Pablo 
dc.contributor.authorVelázquez Blázquez, José Sebastián 
dc.contributor.authorAlió del Barrio, Jorge Luis 
dc.contributor.authorCavas Martínez, Francisco 
dc.contributor.authorAlió Sanz, Jorge Luciano
dc.identifier.citationAlifa R, Piñero D, Velázquez J, Alió del Barrio JL, Cavas F, Alió JL. Changes in the 3D Corneal Structure and Morphogeometric Properties in Keratoconus after Corneal Collagen Crosslinking. Diagnostics. 2020; 10(6):397. doi:10.3390/diagnostics10060397es_ES
dc.description.abstractKeratoconus is an ectatic disorder that is presently considered one of the most prevalent reasons for keratoplasty. Corneal collagen crosslinking (CXL) is the only proven treatment option available that is capable of halting the progression of the disease by stabilizing the cone in 90% of cases, and by also reducing refractive error and maximal keratometry. This study assesses, by means of a 3D morphogeometric analysis procedure developed by our research team, the corneal structure changes that occur immediately after CXL treatment and during a 6 month follow-up period. A total of 19 eyes from 19 patients diagnosed with keratoconus who underwent CXL were included, and several variables derived from the morphogeometric analysis were calculated and evaluated for the pre-operative, 3 month postoperative, and 6 month postoperative states. Significant reductions were detected in central corneal thickness and corneal spherical-like root mean square (RMS) 3 months after surgery, with non-significant regression of the e_ect afterward. Significant reductions in the total corneal area/volume were found, with some levels of regression after 6 months in certain volumetric parameters. In conclusion, the eyes with higher values for morphogeometric parameters—posterior apex deviation (PAD), anterior minimum thickness point deviation (AMTPD), and posterior mínimum thickness point deviation (PMTPD)—seemed more likely to undergo aberrometric improvement as a result of CXL surgery.es_ES
dc.description.sponsorshipThis publication forms part of the Network for Cooperative Research in Health “OFTARED” – reference: RD16/0008/0012. We were funded by the Instituto de Salud Carlos III and co-funded by the European Regional Development Fund (ERDF), “A way to make Europe”. The author David P. Piñero has been supported by the Ministry of Economy, Industry and Competitiveness of Spain as part of program Ramón y Cajal, RYC-2016-20471.es_ES
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.titleChanges in the 3D corneal structure and morphogeometric properties in keratoconus after corneal collagen crosslinkinges_ES
dc.subjectAnterior segmentes_ES
dc.subject.otherExpresión Gráfica en Ingenieríaes_ES
dc.subject.unesco2209 Ópticaes_ES
dc.contributor.funderInstituto de Salud Carlos IIIes_ES
dc.contributor.funderFondo Europeo de Desarrollo Regional (FEDER)es_ES

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Atribución-NoComercial-SinDerivadas 3.0 España
Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 España