A microphysiological model designed for the research of angiogenic sprouting in an extracellular matrix
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We gratefully acknowledge the financial support from the Spanish Ministry of Science and Innovation (MICINN) and the Spanish State Research Agency (AEI) through grants RTI2018-097038-B-C22, PID2021-124575OB-I00 and PDC2022-133918-C22, and the the financial support from the European Union’s Horizon Europe research & innovation program (EIC-2021-PATHFINDER-OPEN- 01-01-101047099 4DBR). Finally, we also appreciate the support of Research Foundation Flanders (FWO) (1SH3W24N).Fecha de publicación
2023-11Editorial
Universidad Politécnica de CartagenaCita bibliográfica
NOGUERA MONTEAGUDO, A., et. al. A microphysiological model designed for the research of angiogenic sprouting in an extracellular matrix. En: XLI Congreso Anual de la Sociedad Española de Ingeniería Biomédica. Cartagena: Universidad Politécnica de Cartagena, 2023. Pp. 630-633. ISBN: 978-84-17853-76-1Palabras clave
Angiogenesis3D hydrogels
Platform
Mathematical model
Resumen
Angiogenesis is an important biological process for vascular
development, as well as being involved in different health
problems such as cancer, inflammatory processes, infections, and
some autoimmune diseases, among others. In recent years,
microphysiological devices have been proposed to study
angiogenesis due to their ability to accurately recreate in vivo
microenvironmental conditions. This study presents a platform to
study the early stages of angiogenesis together with an in-silico
model, presenting an innovative approach that allows us to better
analyze the dynamics of angiogenesis. The presented platform
allows the formation of an angiogenic gradient through a porous
hydrogel, thus provoking the angiogenic response of endothelial
cells and therefore studying the process under the desired
conditions. In addition, the use of the two-photon polymerization
technique has allowed us to print 3D hydrogels with the desired
structure within microfluidic ...
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