A microphysiological setup to mimic, test and analyze myocardial tissue for cardiovascular diseases
Author
Yanac Huertas, E.; Roquette, M.; Vilche Mariscal, A.; Lloveras Borràs, B.; Noguera Monteagudo, A.; [et al.]Knowledge Area
Tecnología ElectrónicaSponsors
We gratefully acknowledge the financial support from the Spanish Ministry of Science and Innovation (MICINN) and the Spanish State Research Agency (AEI) through grants PID2021-124575OB-I00 and PDC2022-133918- C22.Publication date
2023-11Publisher
Universidad Politécnica de CartagenaBibliographic Citation
YANAC HUERTAS, E., et. al. A microphysiological setup to mimic, test and analyze myocardial tissue for cardiovascular diseases. En: XLI Congreso Anual de la Sociedad Española de Ingeniería Biomédica. Cartagena: Universidad Politécnica de Cartagena, 2023. Pp. 570-573. ISBN: 978-84-17853-76-1Keywords
Myocardial tissueCardiovascular diseases
Drug testing
GCampp6-infected cardiomyocytes
Methacrylated gelatin (GelMa)
Abstract
Creating cardiac tissue models for drug testing before clinical
trials is still a major challenge in drug discovery. This is mainly
because it is difficult to replicate the complex nature of cardiac
tissue in a lab setting. One of the biggest challenges is
accurately mimicking the functional features of the heart
muscle. This is largely due to the immaturity of the cells used in
these models, which makes it difficult to get reliable results that
can be translated to human patients. Currently, in vivo models
are the gold standard for evaluating new treatments. However,
it is widely accepted that these animal models cannot fully
reproduce human physiological responses. As a result, this
mismatch often leads to failures in subsequent clinical trials. In
this work, we designed two cardiac culture experiments, using
GCampp6-infected cardiomyocytes, on a microfluidic chip. One
of them is an aligned 2D model, and the other is a 3D tissue
grown in a hydrogel of ...
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