TY - JOUR 
A1 - Cavas Martínez, Francisco
AU - Piñero Llorens, David Pablo
AU - Velázquez Blázquez, José Sebastián
AU - Mira Pérez, Jorge
AU - Alió Sanz, Jorge Luciano
T1 - Relationship between corneal morphogeometrical properties and biomechanical parameters derived from dynamic bidirectional air applanation measurement procedure in keratoconus
Y1 - 2020
SN - 2075-4418
UR - http://hdl.handle.net/10317/9330
AB - The morphogeometric analysis of the corneal structure has become a clinically relevant diagnostic procedure in keratoconus (KC) as well as the in vivo evaluation of the corneal biomechanical properties. However, the relationship between these two types of metrics is still not well understood. The current study investigated the relationship of corneal morphogeometry and volume with two biomechanical parameters: corneal hysteresis (CH) and corneal resistance factor (CRF), both provided by an Ocular Response Analyzer (Reichert). It included 109 eyes from 109 patients (aged between 18 and 69 years) with a diagnosis of keratoconus (KC) who underwent a complete eye examination including a comprehensive corneal topographic analysis with the Sirius system (CSO). With the topographic information obtained, a morphogeometric and volumetric analysis was performed, defining di_erent variables of clinical use. CH and CRF were found to be correlated with these variables, but this correlation was highly influenced by corneal thickness. This suggests that the mechanical properties of KC cornea contribute only in a partial and limited manner to these biomechanical parameters, being mostly influenced by morphogeometry under normal intraocular pressure levels. This would explain the limitation of CH and CRF as diagnostic tools for the detection of incipient cases of KC.
KW - Expresión Gráfica en Ingeniería
KW - Keratoconus
KW - Corneal hysteresis
KW - Corneal biomechanics
KW - Corneal volume
KW - Corneal morphogeometry
KW - 3201.09 Oftalmología
KW - 1203.09 Diseño Con Ayuda del Ordenador
LA - eng
PB - MDPI
ER -