TY - JOUR 
A1 - Bataille, Laurent Guy Françoise
AU - Cavas Martínez, Francisco
AU - García Fernández Pacheco, Daniel
AU - Fernández Cañavate, Francisco José
AU - Alió Sanz, Jorge Luciano
T1 - A study for parametric morphogeometric operators to assist the detection of keratoconus
Y1 - 2017
SN - 2073-8994
UR - http://hdl.handle.net/10317/6723
AB - The aim of this study is to describe a new keratoconus detection method based on the analysis of certain parametric morphogeometric operators extracted from a custom patient-specific three-dimensional (3D) model of the human cornea. A corneal geometric reconstruction is firstly performed using zonal functions and retrospective Scheimpflug tomography data from 107 eyes of 107 patients. The posterior corneal surface is later analysed using an optimised computational geometry technique and the morphology of healthy and keratoconic corneas is characterized by means of geometric variables. The performance of these variables as predictors of a new geometric marker is assessed through a receiver operating characteristic (ROC) curve analysis and their correlations are analysed through Pearson or Spearman coefficients. The posterior apex deviation variable shows the best keratoconus diagnosis capability. However, the strongest correlations in both healthy and pathological corneas are provided by the metrics directly related to the thickness as the sagittal plane area at the apex and the sagittal plane area at the minimum thickness point. A comparison of the screening of keratoconus provided by the Sirius topographer and the detection of corneal ectasia using the posterior apex deviation parameter is also performed, demonstrating the accuracy of this characterization as an effective marker of the diagnosis and ectatic disease progression.
KW - Expresión Gráfica en Ingeniería
KW - Geometric modelling
KW - Cornea reconstruction
KW - Diagnosis
KW - Scheimpflug
KW - Computer-aided design
KW - 3201.09 Oftalmología
LA - eng
PB - Molecular Diversity Preservation International
ER -