Assessment of the association between In vivo corneal morphogeometrical changes and keratoconus eyes with severe visual limitation
ISSN: 2090-004X (impreso)
ISSN: 2090-0058 (electrónico)
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AuthorVelázquez Blázquez, José Sebastián; Cavas Martínez, Francisco; Alió del Barrio, Jorge Luis; García Fernández Pacheco, Daniel; Alió Sanz, Jorge Luciano
Knowledge AreaExpresión Gráfica en Ingeniería
SponsorsThis publication has been carried out in the framework of the Thematic Network for Cooperative Research in Health (RETICS) reference number RD16/0008/0012 financed by the Carlos III Health Institute-General Subdirection of Networks and Cooperative Investigation Centers (R&D&I National Plan 2013–2016) and the European Regional Development Fund (FEDER).
PublisherEd. Hindawi Publishing
Assessing changes suffered by the cornea as keratoconus progresses has proven to be vital for this disease diagnosis and treatment. 'is study determines the corneal biometric profile in eyes considered as affected by keratoconus (KC) showing severe visual limitation, by means of in vivo 3D modelling techniques. 'is observational case series study evaluated new objective indices in 50 healthy and 30 KC corneas, following a validated protocol created by our research group, which has been previously used for diagnosis and characterization of KC in asymptomatic (preclinical) and mild visually impaired eyes. Results show a statistically significant reduction of corneal volume and an increase of total corneal area in the severe KC group, being anterior and posterior corneal surfaces minimum thickness points the best correlated parameters, although with no discrimination between groups. Receiving operator curves were used to determine sensitivity and specificity of selected indices, being ...
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