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dc.contributor.authorBataille, Laurent Guy Françoise 
dc.contributor.authorCavas Martínez, Francisco 
dc.contributor.authorGarcía Fernández Pacheco, Daniel 
dc.contributor.authorFernández Cañavate, Francisco José 
dc.contributor.authorAlió Sanz, Jorge Luciano 
dc.date.accessioned2018-03-08T08:39:51Z
dc.date.available2018-03-08T08:39:51Z
dc.date.issued2017-12
dc.identifier.citationBATAILLE, Laurent et al. A study for parametric morphogeometric operators to assist the detection of keratoconus, 2017. En: Symmetry, vol. 9, n. 12, pp. 302es_ES
dc.identifier.issn2073-8994
dc.description.abstractThe aim of this study is to describe a new keratoconus detection method based on the analysis of certain parametric morphogeometric operators extracted from a custom patient-specific three-dimensional (3D) model of the human cornea. A corneal geometric reconstruction is firstly performed using zonal functions and retrospective Scheimpflug tomography data from 107 eyes of 107 patients. The posterior corneal surface is later analysed using an optimised computational geometry technique and the morphology of healthy and keratoconic corneas is characterized by means of geometric variables. The performance of these variables as predictors of a new geometric marker is assessed through a receiver operating characteristic (ROC) curve analysis and their correlations are analysed through Pearson or Spearman coefficients. The posterior apex deviation variable shows the best keratoconus diagnosis capability. However, the strongest correlations in both healthy and pathological corneas are provided by the metrics directly related to the thickness as the sagittal plane area at the apex and the sagittal plane area at the minimum thickness point. A comparison of the screening of keratoconus provided by the Sirius topographer and the detection of corneal ectasia using the posterior apex deviation parameter is also performed, demonstrating the accuracy of this characterization as an effective marker of the diagnosis and ectatic disease progression.es_ES
dc.description.sponsorshipThis work was supported by the Thematic Network for Co-Operative Research in Health (RETICS-RD16/0008/0012), financed by the Carlos III Health Institute and the European Regional Development Fund (FEDER).es_ES
dc.formatapplication/pdfes_ES
dc.language.isoenges_ES
dc.publisherMolecular Diversity Preservation Internationales_ES
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.titleA study for parametric morphogeometric operators to assist the detection of keratoconuses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.subject.otherExpresión Gráfica en Ingenieríaes_ES
dc.subjectGeometric modellinges_ES
dc.subjectCornea reconstructiones_ES
dc.subjectDiagnosises_ES
dc.subjectScheimpfluges_ES
dc.subjectComputer-aided designes_ES
dc.identifier.urihttp://hdl.handle.net/10317/6723
dc.contributor.investgroupGrupo de investigación en Ingeniería Multidisciplinar y Seguridades_ES
dc.identifier.doi10.3390/sym9120302
dc.identifier.urlhttp://www.mdpi.com/2073-8994/9/12/302
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.type.versioninfo:eu-repo/semantics/publishedVersiones_ES
dc.relation.projectIDRETICS-RD16/0008/0012es_ES
dc.subject.unesco3201.09 Oftalmologíaes_ES
dc.contributor.convenianteVISSUM Instituto Oftalmológico de Alicantees_ES
dc.contributor.convenianteUniversidad Miguel Hernández de Elchees_ES
dc.contributor.funderInstituto de Salud Carlos IIIes_ES
dc.contributor.funderFondo Europeo de Desarrollo Regionales_ES


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