TY - JOUR A1 - Cavas Martínez, Francisco AU - García Fernández Pacheco, Daniel AU - Fernández Cañavate, Francisco José AU - Velázquez Blázquez, José Sebastián AU - Bolarín Guillén, José Miguel AU - Alió Sanz, Jorge Luciano T1 - Study of morpho-geometric variables to improve the diagnosis in keratoconus with mild visual limitation Y1 - 2018 SN - 2073-8994 UR - http://hdl.handle.net/10317/8966 AB - The validation of new methods for the diagnosis of incipient cases of Keratoconus (KC) with mild visual limitation is of great interest in the field of ophthalmology. During the asymmetric progression of the disease, the current diagnostic indexes do not record the geometric decompensation of the corneal curvature nor the variation of the spatial profile that occurs in singular points of the cornea. The purpose of this work is to determine the structural characterization of the asymmetry of the disease by using morpho-geometric parameters in KC eyes with mild visual limitation including using an analysis of a patient-specific virtual model with the aid of computer-aided design (CAD) tools. This comparative study included 80 eyes of patients classified as mild KC according to the degree of visual limitation and a control group of 122 eyes of normal patients. The metric with the highest area under the receiver operating characteristic (ROC) curve was the posterior apex deviation. The most prominent correlation was found between the anterior and posterior deviations of the thinnest point for the mild keratoconic cases. This new custom computational approach provides the clinician with a three-dimensional view of the corneal architecture when the visual loss starts to impair. KW - Expresión Gráfica en Ingeniería KW - Geometric model KW - Asymmetric evolution KW - Computer-aided design KW - Corneal topographer KW - 1203.09 Diseño Con Ayuda del Ordenador KW - 3201.09 Oftalmología LA - eng PB - MDPI ER -