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dc.contributor.authorVelázquez Blázquez, José Sebastián 
dc.contributor.authorGarcía Fernández Pacheco, Daniel 
dc.contributor.authorAlió del Barrio, Jorge Luis 
dc.contributor.authorAlió Sanz, Jorge Luciano 
dc.contributor.authorCavas Martínez, Francisco
dc.identifier.citationVELÁZQUEZ BLÁZQUEZ, José Sebastián et al. Efficacy of Morpho-Geometrical Analysis of the Corneal Surfaces in Keratoconus Disease According to Moderate Visual Limitation. En: Lecture Notes in Mechanical Engineering. Springer, Cham, 2020. 10.1007/978-3-030-41200-5_29es_ES
dc.description.abstractThe cornea is a complex hemispheric structure, made of collagen fibres that provide it a homogenous and stable geometry. During keratoconus disease, a loss of tenacity takes place in the collagen fibres that form the corneal structure, producing an alteration of its geometry, this is, a change of its curvature, and therefore, a loss of visual quality of patients. The geometric characterization of the hemispheric structure by means of biometric parameters is a very solid technique of diagnosis, based in a virtual 3D model, which has already been validated for several degrees of severity of keratoconus pathology. In this prospective comparative study, 93 corneas (50 healthy subjects and 43 patients with keratoconus with moderate visual limitation) were geometrically modelled. The results obtained in this work suggest that the best predictive biometric parameters are anterior corneal surface area and posterior apex deviation, and that the strongest correlation is produced between sagittal plane apex area in minimum thickness point and sagittal plane apex area. The studied biometric parameters have shown significant differences between groups. Therefore, the analysis of the biometric parameters that register the geometric decompensation that locally appear in a corneal region, as a response to the asymmetry produced during the development of keratoconus disease with a moderate visual impairment, is a new approach that may lead to a better understanding of the disease with this degree of optical limitation.es_ES
dc.description.sponsorshipThis publication has been carried out in the framework of the Thematic Network for Co-Operative Research in Health (RETICS) reference number RD16/0008/0012 financed by the Carlos III Health Institute-General Subdirection of Networks and Cooperative Investigation Centres (R&D&I National Plan 2013-2016) and the European Regional Development Fund (FEDER).es_ES
dc.publisherSpringer International Publishinges_ES
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España
dc.titleEfficacy of morpho-geometrical analysis of the corneal surfaces in keratoconus disease according to moderate visual limitationes_ES
dc.subject.otherExpresión Gráfica en Ingenieríaes_ES
dc.subjectComputer-Aided Geometric Design (CAGD)es_ES
dc.subjectOptical aberrometryes_ES
dc.subject3D Modellinges_ES
dc.subject.unesco2209 Ópticaes_ES
dc.subject.unesco1203.09 Diseño Con Ayuda del Ordenadores_ES
dc.contributor.convenianteUniversidad Miguel Hernández de Elchees_ES
dc.contributor.funderInstituto de salud Carlos IIIes_ES
dc.contributor.funderFondo Europeo de Desarrollo Regional‏ (FEDER)es_ES

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Atribución-NoComercial-SinDerivadas 3.0 España
Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 España