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dc.contributor.authorCavas Martínez, Francisco 
dc.contributor.authorPiñero Llorens, David Pablo 
dc.contributor.authorVelázquez Blázquez, José Sebastián 
dc.contributor.authorMira Pérez, Jorge 
dc.contributor.authorAlió Sanz, Jorge Luciano 
dc.date.accessioned2021-04-28T10:43:45Z
dc.date.available2021-04-28T10:43:45Z
dc.date.issued2020
dc.identifier.citationCavas F, Piñero D, Velázquez JS, Mira J, Alió JL. Relationship between Corneal Morphogeometrical Properties and Biomechanical Parameters Derived from Dynamic Bidirectional Air Applanation Measurement Procedure in Keratoconus. Diagnostics. 2020; 10(9):640. https://doi.org/10.3390/diagnostics10090640es_ES
dc.identifier.issn2075-4418
dc.description.abstractThe morphogeometric analysis of the corneal structure has become a clinically relevant diagnostic procedure in keratoconus (KC) as well as the in vivo evaluation of the corneal biomechanical properties. However, the relationship between these two types of metrics is still not well understood. The current study investigated the relationship of corneal morphogeometry and volume with two biomechanical parameters: corneal hysteresis (CH) and corneal resistance factor (CRF), both provided by an Ocular Response Analyzer (Reichert). It included 109 eyes from 109 patients (aged between 18 and 69 years) with a diagnosis of keratoconus (KC) who underwent a complete eye examination including a comprehensive corneal topographic analysis with the Sirius system (CSO). With the topographic information obtained, a morphogeometric and volumetric analysis was performed, defining di_erent variables of clinical use. CH and CRF were found to be correlated with these variables, but this correlation was highly influenced by corneal thickness. This suggests that the mechanical properties of KC cornea contribute only in a partial and limited manner to these biomechanical parameters, being mostly influenced by morphogeometry under normal intraocular pressure levels. This would explain the limitation of CH and CRF as diagnostic tools for the detection of incipient cases of KC.es_ES
dc.description.sponsorshipThis publication was carried out in the framework of the Thematic Network for Co-Operative Research in Health (RETICS) reference number RD12/0034/0007 and RD16/0008/0012, financed by the Carlos III Health Institute—General Subdirection of Networks and Cooperative Investigation Centers (R&D&I National Plan 2008–2011) and the European Regional Development Fund (FEDER). The author David P. Piñero has been supported by the Ministry of Economy, Industry, and Competitiveness of Spain within the program Ramón y Cajal, RYC-2016-20471.es_ES
dc.formatapplication/pdfes_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.titleRelationship between corneal morphogeometrical properties and biomechanical parameters derived from dynamic bidirectional air applanation measurement procedure in keratoconuses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.subjectKeratoconuses_ES
dc.subjectCorneal hysteresises_ES
dc.subjectCorneal biomechanicses_ES
dc.subjectCorneal volumees_ES
dc.subjectCorneal morphogeometryes_ES
dc.subject.otherExpresión Gráfica en Ingenieríaes_ES
dc.identifier.urihttp://hdl.handle.net/10317/9330
dc.identifier.doi10.3390/diagnostics10090640
dc.identifier.urlhttps://www.mdpi.com/2075-4418/10/9/640
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersiones_ES
dc.subject.unesco3201.09 Oftalmologíaes_ES
dc.subject.unesco1203.09 Diseño Con Ayuda del Ordenadores_ES
dc.contributor.funderInstituto de Salud Carlos IIIes_ES
dc.contributor.funderFondo Europeo de Desarrollo Regional (FEDER)es_ES


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