Mostrar el registro sencillo del ítem
Assessment of the association between In vivo corneal morphogeometrical changes and keratoconus eyes with severe visual limitation
dc.contributor.author | Velázquez Blázquez, José Sebastián | |
dc.contributor.author | Cavas Martínez, Francisco | |
dc.contributor.author | Alió del Barrio, Jorge Luis | |
dc.contributor.author | García Fernández Pacheco, Daniel | |
dc.contributor.author | Alió Sanz, Jorge Luciano | |
dc.date.accessioned | 2020-12-09T11:30:14Z | |
dc.date.available | 2020-12-09T11:30:14Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 2090-004X (impreso) | |
dc.identifier.issn | 2090-0058 (electrónico) | |
dc.description.abstract | Assessing changes suffered by the cornea as keratoconus progresses has proven to be vital for this disease diagnosis and treatment. 'is study determines the corneal biometric profile in eyes considered as affected by keratoconus (KC) showing severe visual limitation, by means of in vivo 3D modelling techniques. 'is observational case series study evaluated new objective indices in 50 healthy and 30 KC corneas, following a validated protocol created by our research group, which has been previously used for diagnosis and characterization of KC in asymptomatic (preclinical) and mild visually impaired eyes. Results show a statistically significant reduction of corneal volume and an increase of total corneal area in the severe KC group, being anterior and posterior corneal surfaces minimum thickness points the best correlated parameters, although with no discrimination between groups. Receiving operator curves were used to determine sensitivity and specificity of selected indices, being anterior and posterior apex deviations the ones which reached the highest area under the curve, both with very high sensitivity (96.7% and 90%, respectively) and specificity (94.0% and 99.9%, respectively). 'e results suggest that once severe visual loss appears, anterior corneal topography should be considered for a more accurate diagnosis of clinical KC, being anterior apex deviation the key metric discriminant. 'is study can be a useful tool for KC classification, helping doctors in diagnosing severe cases of the disease, and can help to characterize corneal changes that appear when severe KC is developed and how they relate with vision deterioration. | es_ES |
dc.description.sponsorship | This publication has been carried out in the framework of the Thematic Network for Cooperative Research in Health (RETICS) reference number RD16/0008/0012 financed by the Carlos III Health Institute-General Subdirection of Networks and Cooperative Investigation Centers (R&D&I National Plan 2013–2016) and the European Regional Development Fund (FEDER). | es_ES |
dc.format | application/pdf | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Ed. Hindawi Publishing | es_ES |
dc.relation.ispartof | Análisis morfogeométrico de la estructura hemiesférica del segmento anterior del ojo humano y su aplicación clínica | es_ES |
dc.rights | Atribución-NoComercial-SinDerivadas 3.0 España | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.title | Assessment of the association between In vivo corneal morphogeometrical changes and keratoconus eyes with severe visual limitation | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.subject.other | Expresión Gráfica en Ingeniería | es_ES |
dc.subject | Ophthalmology | es_ES |
dc.subject | Early keratoconus | es_ES |
dc.subject | Keratoconus (KC) | es_ES |
dc.subject | Corneal topographer | es_ES |
dc.identifier.uri | http://hdl.handle.net/10317/8968 | |
dc.identifier.doi | 10.1155/2019/8731626 | |
dc.identifier.url | https://www.hindawi.com/journals/joph/2019/8731626/ | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.subject.unesco | 1203.09 Diseño Con Ayuda del Ordenador | es_ES |
dc.subject.unesco | 3201.09 Oftalmología | es_ES |
dc.contributor.funder | Instituto de salud Carlos III | es_ES |
dc.contributor.funder | Fondo Europeo de Desarrollo Regional (FEDER) | es_ES |
Ficheros en el ítem
Este ítem aparece en la(s) siguiente(s) colección(ones)
-
Artículos [1734]
Redes sociales