Study and characterization of morphogeometric parameters to assist diagnosis of keratoconus
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AuthorCavas Martínez, Francisco; García Fernández Pacheco, Daniel; Parras Burgos, Dolores; Fernández Cañavate, Francisco José; Bataille, Laurent Guy Françoise; [et al.]
Knowledge AreaExpresión Gráfica en Ingeniería
SponsorsThis publication has been carried out in the framework of the Thematic Network for Co-Operative Research in Health (RETICS) reference number RD16/0008/0012, financed by the Carlos III Health Institute—General Subdirection of Networks and Cooperative Investigation Centers (R&D&I National Plan 2008-2011) and the European Regional Development Fund (FEDER).
PublisherBMC Part of Springer Nature
Bibliographic CitationCavas‑Martínez et al. BioMed Eng OnLine 2018, 17(Suppl 1):161 https://doi.org/10.1186/s12938-018-0564-7
Background: In case of signifcant imperfections on the cornea, data acquisition is difcult and a signifcant level of missing data could require the interpolation of important areas of the cornea, resulting in a very ambiguous model. The development of methods to defne in vivo customised geometric properties of the cornea based only on real raw data is extremely useful to diagnose and assess the progression of diseases directly related to the corneal architecture. The present work tries to improve the prognostic of corneal ectasia creating a 3D customised model of the cornea and analysing diferent geometric variables from this model to determine which variables or combination of them could be defned as an indicator of susceptibility to develop keratoconus. Methods: A corneal geometric reconstruction was performed using zonal functions and retrospective Scheimpfug tomography data from 187 eyes of 187 patients. Mor‑ phology of healthy and keratoconic corneas was characterized ...
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