A study for parametric morphogeometric operators to assist the detection of keratoconus
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AuthorBataille, Laurent Guy Françoise; Cavas Martínez, Francisco; García Fernández Pacheco, Daniel; Fernández Cañavate, Francisco José; Alió Sanz, Jorge Luciano
Research GroupGrupo de investigación en Ingeniería Multidisciplinar y Seguridad
Knowledge AreaExpresión Gráfica en Ingeniería
SponsorsThis work was supported by the Thematic Network for Co-Operative Research in Health (RETICS-RD16/0008/0012), financed by the Carlos III Health Institute and the European Regional Development Fund (FEDER).
Realizado en/conVISSUM Instituto Oftalmológico de Alicante; Universidad Miguel Hernández de Elche
PublisherMolecular Diversity Preservation International
Bibliographic CitationBATAILLE, Laurent et al. A study for parametric morphogeometric operators to assist the detection of keratoconus, 2017. En: Symmetry, vol. 9, n. 12, pp. 302
The aim of this study is to describe a new keratoconus detection method based on the analysis of certain parametric morphogeometric operators extracted from a custom patient-specific three-dimensional (3D) model of the human cornea. A corneal geometric reconstruction is firstly performed using zonal functions and retrospective Scheimpflug tomography data from 107 eyes of 107 patients. The posterior corneal surface is later analysed using an optimised computational geometry technique and the morphology of healthy and keratoconic corneas is characterized by means of geometric variables. The performance of these variables as predictors of a new geometric marker is assessed through a receiver operating characteristic (ROC) curve analysis and their correlations are analysed through Pearson or Spearman coefficients. The posterior apex deviation variable shows the best keratoconus diagnosis capability. However, the strongest correlations in both healthy and pathological corneas are provided by ...
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