%0 Journal Article 
%A Cavas Martínez, Francisco
%A García Fernández Pacheco, Daniel
%A Parras Burgos, Dolores
%A Fernández Cañavate, Francisco José
%A Bataille, Laurent Guy Françoise
%A Alió Sanz, Jorge Luciano
%T Study and characterization of morphogeometric parameters to assist diagnosis of keratoconus
%D 2018
%@ 1475-925X
%U http://hdl.handle.net/10317/7761
%X Background: In case of signifcant imperfections on the cornea, data acquisition
is difcult and a signifcant level of missing data could require the interpolation of
important areas of the cornea, resulting in a very ambiguous model. The development
of methods to defne in vivo customised geometric properties of the cornea based
only on real raw data is extremely useful to diagnose and assess the progression of
diseases directly related to the corneal architecture. The present work tries to improve
the prognostic of corneal ectasia creating a 3D customised model of the cornea and
analysing diferent geometric variables from this model to determine which variables
or combination of them could be defned as an indicator of susceptibility to develop
keratoconus.
Methods: A corneal geometric reconstruction was performed using zonal functions
and retrospective Scheimpfug tomography data from 187 eyes of 187 patients. Mor‑
phology of healthy and keratoconic corneas was characterized by means of geometric
variables. The performance of these variables as predictors of a new geometric marker
was assessed and their correlations were analysed.
Results: The more representative variable to classify the corneal anomalies related to
keratoconus was posterior apex deviation (area under receiver operating characteris‑
tic curve>0.899; p<0.0001). However, the strongest correlations in both healthy and
pathological corneas were provided by the metrics directly related to the thickness, as
deviations of the anterior/posterior minimum thickness points.
Conclusions: The presented morphogeometric approach based on the analysis and
custom geometric modelling of the cornea demonstrates to be useful for the charac‑
terization and diagnosis of keratoconus disease, stating that geometrical deformation
is an efective marker of the ectatic disease’s progression.
%K Expresión Gráfica en Ingeniería
%K Keratoconus
%K Scheimpflug
%K CAD
%K Surface reconstruction
%K Virtual model
%K 6203.04 Dibujo, Grabado
%~ GOEDOC, SUB GOETTINGEN