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dc.contributor.authorLópez Cascales, José Javier 
dc.contributor.authorZenak, Siham 
dc.contributor.authorGarcía de la Torre, José 
dc.contributor.authorGuy Lezama, Osvaldo 
dc.contributor.authorGarro, Adriana 
dc.contributor.authorDaniel Enriz, Ricardo 
dc.date.accessioned2019-05-06T06:37:18Z
dc.date.available2019-05-06T06:37:18Z
dc.date.issued2018-05-18
dc.identifier.citationEn ACS Omega, 2018, 3 (5), pp 5390–5398es_ES
dc.identifier.issn2470-1343
dc.description.abstractThe first stage of the action mechanism of small cationic peptides with antimicrobial activity is ruled by electrostatic interactions between the peptide and the pathogen cell membrane. Thus, an increase in its activity could be expected with an increase in the positive charge on the peptide. By contrast, the opposite behavior has been observed when the charge increases to reach a critical value, beyond which the activity falls. This work studies the perturbation effects in a cell membrane model for two small cationic peptides with similar length and morphology but with different cationic charges. The synthesis and antibacterial activity of the two peptides used in this study are described. The thermodynamic study associated with the insertion of these peptides into the membrane and the perturbing effects on the bilayer structure provide valuable insights into the molecular action mechanism associated with the charge of these small cationic peptides.es_ES
dc.description.sponsorshipThe authors acknowledge the financial support from Fundación Séneca through the grant no. 19353/PI/14.es_ES
dc.formatapplication/pdfes_ES
dc.language.isoenges_ES
dc.publisherAmerican Chemical Societyes_ES
dc.relation.urihttps://pubs.acs.org/doi/full/10.1021/acsomega.8b00293es_ES
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.titleSmall Cationic Peptides: Influence of Charge on Their Antimicrobial Activityes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.subject.otherQuímica-Físicaes_ES
dc.subjectBacteriaes_ES
dc.subjectCell and Molecular biologyes_ES
dc.subjectEnthalpyes_ES
dc.subjectEntropyes_ES
dc.subjectMolecular dynamics simulationes_ES
dc.subjectPeptides and Proteinses_ES
dc.identifier.urihttp://hdl.handle.net/10317/7744
dc.peerreviewSies_ES
dc.identifier.doi10.1021/acsomega.8b00293
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersiones_ES


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Atribución-NoComercial-SinDerivadas 3.0 España
Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 España