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dc.contributor.authorCavas Martínez, Francisco 
dc.contributor.authorBataille, Laurent Guy Françoise 
dc.contributor.authorGarcía Fernández Pacheco, Daniel 
dc.contributor.authorFernández Cañavate, Francisco José 
dc.contributor.authorAlió Sanz, Jorge Luciano 
dc.date.accessioned2018-09-13T08:03:34Z
dc.date.available2018-09-13T08:03:34Z
dc.date.issued2017-11-20
dc.identifier.citationCAVAS MARTÍNEZ, Francisco et al. Keratoconus detection based on a new corneal volumetric analysis. En: Scientific reports, vol. 7, n.1, 2017. ISSN: 2045-2322es_ES
dc.identifier.issn2045-2322
dc.description.abstractThere are numerous tomographic indices for the detection of keratoconus risk. When the indexes based on corneal volume are analyzed, two problems are presented: on the one hand, they are not very sensitive to the detection of incipient cases of keratoconus because they are not locally defined in the primary developmental region of the structural abnormalities; and on the other hand, they do not register the geometric decompensation driven by the asymmetry present during the disease progression. This work performed a morphogeometric modeling of the cornea by the aid of CAD tools and using raw topographic data (Sirius system, CSO, Firenze). For this method, four singular points present on the corneal surfaces were located and the following parameters based on corneal volume were calculated: VOLmct, defined by the points of minimal thickness; VOLaap, defined by the anterior corneal apex, and VOLpap, defined by the posterior corneal apex. The results demonstrate that a further reduction of corneal volume in keratoconus happens and significantly progresses along the disease severity level. The combination of optical and volumetric data, that collect the sensitivity of the asymmetry generated by the disease, allows an accurate detection of incipient cases and follow up of the disease progression.es_ES
dc.description.sponsorshipThis publication has been carried out in the framework and with the financial support of the Thematic Network for Co-Operative Research in Health (RETICS) reference number RD16/0008/0012, financed by the Carlos III Health Institute – General Subdirection of Networks and Cooperative Investigation Centers (R&D&I National Plan 2008–2011) and the European Regional Development Fund (FEDER).es_ES
dc.formatapplication/pdfes_ES
dc.language.isoenges_ES
dc.publisherNature Publishing Groupes_ES
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rightsCopyright © 2017 Nature Publishing Groupes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.titleKeratoconus detection based on a new corneal volumetric analysises_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.subject.otherExpresión Gráfica en Ingenieríaes_ES
dc.subjectPachymetric parameterses_ES
dc.subjectScheimpflug tomographyes_ES
dc.subjectClinical keratoconuses_ES
dc.subjectThicknesses_ES
dc.subjectTopographyes_ES
dc.subjectAnteriores_ES
dc.subjectBiomechanicses_ES
dc.subjectAberrationses_ES
dc.subjectIndexeses_ES
dc.subjectSystemes_ES
dc.identifier.urihttp://hdl.handle.net/10317/7209
dc.identifier.doi10.1038/s41598-017-16145-3
dc.identifier.urlhttps://www.nature.com/articles/s41598-017-16145-3
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersiones_ES
dc.relation.projectIDRD16/0008/0012es_ES
dc.subject.unesco2209 Ópticaes_ES
dc.contributor.funderInstituto de Salud Carlos IIIes_ES
dc.contributor.funderFondo Europeo de Desarrollo Regional‏es_ES
dc.contributor.funderMinisterio de Ciencia e Innovaciónes_ES


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